Refiners worldwide are brainstorming how varieties of crude oils, including the cheaper ones available at market, can be processed so that input cost gets minimized .Opportunity crude are heavy crudes (Low API gravity), containing high sulfur and TAN (Total Acid No.). These are available at relatively cheaper rate in the global oil market, and are processed in primary and secondary units to obtain best possible product yield. However, while processing these crudes, chances of corrosion related damages in various sections of distillation units, gets aggravated, which is an area of concern. When the crude is heavy, the situation further worsens because desalting of heavy crude becomes extremely difficult. Managing corrosion while processing opportunity crude oils is a challenge to refiners. The paper discusses various aspects of corrosion management in processing such crudes which comprises a) overall corrosion mechanisms operating in crude distillation units in general and stresses on how it gets affected when opportunity crudes (heavy, high sulfur and acidic crudes) are processed b) effective desalter management and its role in minimizing corrosion c) monitoring and control of various process parameters to have an assessment of ongoing corrosion damages including role of corrosion inhibitors and chemicals etc.